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Researchers at Ocean University of China have developed edible macroporous microcarriers (EPMs) that aim to revolutionise the production of cultured fish fillets.


This innovation addresses the pressing challenges of protein scarcity and environmental sustainability, key concerns as global demand for alt-protein sources continues to rise.


Published in Nature Communications, the study reveals that these new microcarriers enable the large-scale expansion of muscle satellite cells and adipose-derived stem cells, achieving an impressive 499-fold increase in muscle cells and a 461-fold increase in fat cells.


This capability is crucial for meeting the increasing consumer demand for sustainable seafood alternatives.

Photographs of scaled-up and matured microtissues as raw material for cultured fish fillets product manufacturing. For (a, b, d, e), n = 3 independent experiments, error bars indicate means ± SD. Credit: Ocean University of China
Photographs of scaled-up and matured microtissues as raw material for cultured fish fillets product manufacturing. For (a, b, d, e), n = 3 independent experiments, error bars indicate means ± SD. Credit: Ocean University of China

Highlights from the research


Scalable production: The EPMs facilitate a highly efficient cell cultivation process, which is vital for the commercial viability of cultivated meat. The study demonstrated that these microcarriers support cell densities that largely exceed those achieved with traditional methods.


3D printing capabilities: Leveraging the matured microtissues, researchers successfully utilised 3D printing technology to create cultured fish fillets that closely replicate the texture and flavor of conventional fish. This breakthrough could pave the way for more diverse and appealing products in the cultivated meat market.


Nutritional benefits: The cultivated fish fillets produced using this method exhibited reduced fat and cholesterol levels compared to their traditional counterparts, while also providing higher levels of essential amino acids. This aligns with the growing consumer preference for healthier protein options.


Sustainable practices: The use of fish gelatin sourced from food processing waste as the microcarrier matrix underscores a commitment to sustainability. This approach not only reduces food waste but also mitigates the environmental impact associated with conventional aquaculture.

Photograph of biotech-5JGC-7000ASC System (Baoxing bio-engineering, China) with a 5 L glass vessel. Credit: Ocean University of China
Photograph of biotech-5JGC-7000ASC System (Baoxing bio-engineering, China) with a 5 L glass vessel. Credit: Ocean University of China

Industry implications


The findings from this study represent a pivotal moment for cultivated food manufacturers, offering a scalable solution that meets both market demands and sustainability goals.


As the industry continues to evolve, the integration of innovative technologies like EPMs could enhance production efficiency and product quality, ultimately transforming how consumers access protein-rich foods.


This research not only highlights the potential of cultivated meat but also sets the stage for future advancements in cellular agriculture, positioning it as a viable alternative to traditional animal farming.


#research #cultivatedfishfillets #microcarriers #stemcells #cellularagriculture

Edible microcarriers could enhance scalability for cultivated fish fillets

Sian Yates

20 February 2025

Edible microcarriers could enhance scalability for cultivated fish fillets

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